Abstract

Background: in patients with congestive heart failure (CHF), there is a change in indicators of heart mechanics against the background of myocardium remodeling. Currently, magnetic resonance imaging (MRI) and speckle tracking echocardiography provide additional options for assessing changes in heart mechanics. Evaluation of mechanics of the myocardium rotational movement according to coronarography (CAG) has not been found in available literature. In this regard, there is a need to develop a methodology that allows to obtain a mathematical description of rotation processes and heartbeat during the CAG.

Material and methods: study included 90 patients aged 30-71 to assess indicators of heart rotation mechanics. Subjects were divided into groups: with dilated cardiomyopathy (DCMP, n=30), left ventricular aneurysm (LVA, n=30) and patients with autonomic nervous system disorder (ANSD, n=30) without heart failure (control group). Mechanics of heart rotation was studied using the CAG technique, modified by us, based on mathematical calculations of the rotation angle in motion of points on the heart surface, determined on the coronary angiogram in two projections.

Results: study found out, that in patients with DCMP and LVA with chronic heart failure, the angle of rotation of the heart was significantly lower than in patients with ANSD who do not have heart disease (p <0,05). The link between impaired myocardial contractile function in patients with DCMP and LVA with chronic heart failure and a decrease in the heart rotation angle was confirmed (DCMP: ?²=9,774; df=1; P <0,05), (LVA: ?²=9,600; df=1; P <0,05).

Conclusion: coronarography technique that we modified, makes it possible to quantify changes in parameters of the heart mechanics in examined patients. This makes it possible to determine the presence or absence of heart failure, depending on results.

References 

1.     Fomin IV. Chronic heart failure in the Russian Federation: what we know today and what we should do. Russian Journal of Cardiology. 2016, 8(136): 7-13 [In Russ].

2.     Belenkov YuN, Mareev VYu. Principles of rational treatment of heart failure.M. 2000. 266 [In Russ].

3.     Popescu BA, Beladan CC, Calin A, et al. Left ventricular remodelling and torsional dynamics in dilated cardiomyopathy: reversed apical rotation as a marker of disease severity. EurJHeartFail. 2009;11(10): 945-51.

4.     Pavlyukova EN, Kuzhel' DA, Matyushin GV, Savchenko EA, Filippova SA. Rotation, twisting and spinning of the left ventricle: physiological role and significance in clinical practice. Regional pharmacotherapy in cardiology. 2015; 11(1): 68-78 [In Russ].

5.     Mondillo S, Galderisi M, Mele D, et al.; Echocardiography Study Group Of The Italian Society Of Cardiology (Rome, Italy). Speckle-tracking echocardiography: a new technique for assessing myocardial function. J Ultrasound Med. 2011;30(1):71-83.

6.     Sergio Mondillo, MD, Maurizio Galderis, et al. Speckle-tracking echocardiography - a technique for assessing myocardial function. June 2, 2016. The international online community of specialists in ultrasound diagnostics [In Russ].

7.     Leitman M, Lysyansky P, Sidenko S et al. Two-dimensionalstrain - a novel software for real-time quantitative echocardiographic assessment of myocardial function. J. Am. Soc. Echocardiogr. 2004; 17(10): 1021-1029.

8.     Amundsen BH, Helle-Valle T, Edvardsen T et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J. Am. Coll. Cardiol. 2006; 47(4): 789-793.

9.     Buckberg G.D., Weisfeldt M.L., Ballester M. [et al.] Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease. Circulation. 2004; 110: 333-336.

10.   Mirsky I., Parmley W.W. Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ. Res. 1973; 33: 233-243.

11.   Pouleur A., Knappe D., Shah A. [et al.] Relationship between improvement in left ventricular dyssynchrony and contractile function and clinical outcome with cardiac resynchronization therapy: the MADIT-CRT trial. Eur. Heart J. 2011; 32:1720-29.

12.   Vermes E., Tardif J.C., Bourassa M.G. [et al.] Enalapril decreases the incidence of atrial fibrillation in patients with left ventricular dysfunction: insight from the Studies of Left Ventricular Dysfunction (SOLVD) trials. Circulation. 2003; 931: 2926-2.

13.   Victor Mor-Avi et al. The consensus decision of the American Echocardiographic Society and the European Association of Echocardiography on the methodology and indications, approved by the Japanese Society of Echocardiography. Articles. 07/07/2015 [In Russ].

14.   Roberto M Lang, Michelle Bierig [et al.] Roberto M Lang, Michelle Bierig [et al.]Recommendations for quantifying the structure and chambers of the heart.. Russian Journal of Cardiology 2012; 3(95). This edition of guidelines is published in Eur J Echocardiography 2006; 7: 79-108 [In Russ].

Abstract:

Aim: was to estimate parameters of left ventricle (LV) perfusion and kinetics at ischemic chronic heart failure (CHF), which initial values are predictors of increased myocardial functional reserve and patients clinical status improvement as a result of revascularization.

Materials and methods: examined 157 patients (146 men and 11 women; age from 33 to 72 years) before and in 2 - 3 days after percutaneous coronary intervention with diagnosis: CAD, CHF with NYHA class III-IV echocardiography parameters of LV: ejection fraction less than 40%, end-diastolic volume is more than 200 ml. Perfusion and function disorders were estimated with use of ECG-gated single photon emission computed tomography (SPECT).

Results: in 48% of cases 6-minute walk test increased more than 150%; NYHA class decreased by 2 classes (group 1). In 52% cases 6-minute walk test increased less than 50% and the NYHA class decreased on 1 class or did not change (group 2). Comparison of initial LV condition and clinical effect revealed following conformities. The revascularization effect is limited not to extent of coronary blood flow recovery, but first of all a cardiac muscle condition, the quantitative relation of the functioning myocardium and a focal cardiosclerosis. Thus, critical size to define the favorable forecast of revascularization is perfusion disorder more than a half of LV and kinetics disorder more than a third of cardiac muscle volume. Prevalence of a cardiosclerosis over the functioning myocardium limits clinical effect of a revascularization and growth of a functional reserve.

Conclusion: degree of initial LV myocardium perfusion and movement disorders at patients with severe ischemic heart failure is the key indicator, influencing clinical efficiency of coronary intervention

References

1.     Ageev F.T., Belenkov Yu.N., Fomin I.V., et al. Rasprostranennost hronicheskoj serdechnoj nedostatochnosti v Evropejskoj chaste Rossijskoj Federacii - dannye JEPOHA-HSN [The prevalence of chronic heart failure in the European part of the Russian Federation - Data AGE-CHF]. Serdechnaya nedostatochnost. 2006;7(1):112-115 [In Russ].

2.     Bax J.J., Delgado V. Myocardialviability as integral-part of the diagnostic and therapeutic approach to ischemic heart failure. J Nucl Cardiol. 2015 Apr;22(2): 229-45.

3.     Mareev V.Yu., Danielyan M.O., Belenkov Yu.N., Ot imeni rabochej gruppy issledovaniya JEPOHA-O-HSN. Sravnitelnaya harakteristika bolnyh s HSN v zavisimosti ot velichiny FV po rezultatam Rossijskogo mnogocentrovogo issledovaniya JEPOHA-O-HSN [On behalf of the working group study AGE-O-CHF. Comparative characteristics of patients with CHF, depending on the size of the PV on results of Russian studies mnogotsentrovogo AGE-O-CHF]. Serdechnaya nedostatochnost. 2006;7 (4):164-171 [In Russ].

4.     Samady H., Elefteriades J.A., Abbott B.G., et al. Failure to improve left ventricular function after coronary revascularization for ischemic cardiomyopathy is not associated with worse outcome. Circulation. 1999;100:1298- 304.

5.     Patel H.C., Ellis S.G.Role of revascularization to improveleft ventricular function. Heart Fail Clin. 2015 Apr; 11(2):203-14.

6.     Yancy C.W., Jessup M., Bozkurt B., et al. 2013 ACCF/AHA guideline for the management of heart failure: executive summary. J Am Coll Cardiol 2013;62:1495-539.

7.     McMurray J.J., Adamopoulos S., Anker S.D., et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33:1787-847.

8.     Fonseca C., Morais H., Mota T., Matias F., Costa C., Gouveia-Oliveira A., Ceia F. EPICA Investigators. The diagnosis of heart failure in primary care: value of symptoms and signs. Eur J Heart Fail. 2004 Oct; 6(6):795-800, 821-2.

9.     Shabana A., El-Menyar A. Myocardial viability: what we knew and what is new. Cardiol Res Pract. 2012; 2012:607486.

10.   Ling L.F., Marwick T.H., Flores D.R., Jaber W.A.. Brunken R.C., Cerqueira M.D., Hachamovitch R.Identification of therapeutic benefit from revascularization in patients with left ventricular systolic dysfunction: inducible ischemia versus hibernating myocardium. Circ Cardiovasc Imaging. 2013 May 1;6(3):363-72.

11.   Schinkel A.F., Poldermans D., Rizzello V., Vanoverschelde J.L., Elhendy A., Boersma E., Roelandt J.R., Bax J.J. Why do patients with ischemiccardiomyopathy and a substantialamount of viablemyocardium not always recover in function after revascularization? J Thorac Cardiovasc Surg. 2004 Feb;127(2):385-90.

12.   Mandegar M.H., Yousefnia M.A., Roshanali F., Rayatzadeh H., Alaeddini F. Interaction between two predictors of functional outcome after revascularization in ischemic cardiomyopathy: left ventricular volume and amount of viable myocardium. J Thorac Cardiovasc Surg. 2008 Oct; 136(4):930-6.

13.   Beanlands R.S.B., Dawood F., Wen W.H. et al. Are the kinetics of technetium 99m-methoxy isobutyl isonitrile affected by cell metabolism and viability? Circulation. 1990; 82:1802-1814.

14.   Rizzello V., Schinkel A.F., Bax J.J., et al. «Individual prediction of functional recovery after coronary revascularization in patients with ischemic cardiomyopathy: the scar-to-biphasic model» Am J Cardiol. 2003 Jun 15;91 (12): 1406-9.

15.   Chestuhin V.V., Mironkov A.B., Bljahman F.A., Ostroumov E.N., Kolchanova S.G., Shkljar T.F., Azoev Je.T., Sahovskij S.A. Vlijanie polnoty revaskuljarizacii serdca na funkcional'noe sostojanie miokarda pri ishemicheskoj kardiomiopatii [Influence of completeness of coronary revascularization on the functional state of the myocardium in ischemic cardiomyopathy.]. Vestnik transplantologii i iskusstvennyh organov. 2013: 14(4):55-63 [In Russ].

16.   Bax J.J., Visser F.C., Poldermans D., et al. Time course of functional recovery of stunned and hibernating segments after surgical revascularization. Circulation. 2001; 104(Suppl 1):I314 -8.